First page, text blurred. © 2026 The Author(s), published by Elsevier on behalf of the American Society for Nutrition, CC BY 4.0 license.
Advances in Nutrition
2026
DOI: 10.1016/j.advnut.2026.100613
Review of the Use of Digital Therapeutics for Obesity Treatment: Toward a Psychological Phenotyping
Cédric Plessis, Marie Galmiche, Pierre Déchelotte, Anthony Haro
Digital therapeutics (DTx) offer an innovative opportunity for the prevention and treatment of obesity. However, their efficacy remains limited by a standardized approach that often does not adequately consider interindividual differences in eating behavior, motivation, mental comorbidities, and emotional regulation. This narrative review explores the psychological dimensions involved in obesity and how they may be used to inform personalization strategies in DTx. Through an analysis of existing studies, we identify underexplored psychological dimensions and suggest the integration in DTx to enhance patient assessment and monitoring. Finally, we discuss the clinical and methodological implications of psychological phenotyping, highlighting its value for healthcare professionals.
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